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国内输液制剂用的橡胶塞均为天然橡胶制成,与葡萄糖、氯化钠等输液直接接触常产生小白点,致使澄明度不合格而不能用于注射。为此,药厂在使用橡胶塞时衬一层玻璃纸或涤纶薄膜,以隔离与药液接触。虽然隔离层能够阻止小白点的产生,但在存放较长时间后,由于隔离层有渗透作用,仍然有小白点产生。随着存放时间的增长,小白点也会增多。衬薄膜隔离层不仅不美观,而且对于药厂生产带来很多不便。此外,薄膜在塞入瓶口中很易折皱,尤其是厚度超过10μ时,常因封口不严而导致长霉。所以采用衬垫薄膜的办法并不能彻底解决上述缺陷。
Domestic infusion formulations are made of natural rubber rubber stopper, and glucose, sodium chloride and other infusions direct contact often produce white spots, resulting in clarity failed and can not be used for injection. To this end, the pharmaceutical factory in the use of rubber plug lined with a layer of cellophane or polyester film to isolate contact with the liquid. Although the barrier to prevent the white spots, but stored for a long time, due to the infiltration of the barrier layer, there are still white spots. With the growth of storage time, white spots will increase. Lining film isolation is not only not beautiful, but also brought a lot of inconvenience for the pharmaceutical production. In addition, the film is very easy to crease the bottle into the mouth, especially when the thickness exceeds 10μ, often due to lax sealing caused by mold. Therefore, the use of liner film approach does not completely solve the above shortcomings.