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在广西肝癌高发区壮族自然人群中采集血清标本１７７６人份，同时在该地医院中收集壮族肝病患者血清４５人份。采用ＥＬＩＳＡ方法检测抗－ＨＣＶ、ＰＣＲ技术检测ＨＣＶ－ＲＮＡ，并对其阳性标本（分别为６９、１１份）采用ＨＣＷ型特异性引物进行基因分型。结果显示：当地自然人群中流行的ＨＣＶ基因型以Ⅰ型或Ⅰ型与其它型别的混合感染为主，而病人中则是以Ⅱ型及与Ⅰ型的混合感染为主。此结果表明在不同特征的人群中ＨＣＶ基因型的分布明显不同。
A total of 1776 serum samples were collected from natural populations of the Zhuang population in the high-incidence area of Guangxi, and 45 serum samples from patients with Zhuang liver disease were collected at the same hospital. Anti-HCV and HCV-RNA were detected by ELISA. Positive samples (69 and 11 samples, respectively) were genotyped with specific primers of HCW type. The results showed that the prevalent HCV genotypes in the local natural population were predominantly mixed with type I or type I and other types of infection, while the patients were mainly type II and type I combined infections. This result shows that the distribution of HCV genotypes differs significantly among populations with different characteristics.