综述了近几年固相有机反应和分析方法的最新进展。固相有机反应包括取代、缩合、环加成、氧化还原反应等,可以形成碳碳键、酰胺键等,满足官能团的变换;与固相有机反应相适应的有机分析方法包括对单个树脂微球所连接化合物进行官能团分析(FTIR)方法和结构确定方法(MAS NMR)。这些技术能够更好地使组合化学应用到药物开发研究之中。 The latest progress of solid-phase organic reactions and analytical methods in recent years is reviewed. Solid-state organic reactions include substitution, condensation, cycloaddition, redox reactions, etc., which can form carbon-carbon bonds, amide bonds, etc. to meet the functional group transformation; organic solid phase reaction with organic analytical methods include single resin microspheres The attached compounds are subjected to a functional group analysis (FTIR) method and a structure determination method (MAS NMR). These technologies make it better to apply combinatorial chemistry to drug discovery research.