论文部分内容阅读
氧化应激涉及多种疾病的发生和发展以及人体的衰老过程。DJ-1/PARK7基因编码DJ-1蛋白,研究发现其具有多种生物学功能,包括细胞的恶性转化、雄性精子成熟与受精、促进细胞增殖及抵抗氧化应激等。近年来DJ-1抗氧化应激功能日益受到重视。研究层次包括体外实验、体内实验和临床研究。其机制主要包括自身构型改变、分子伴侣作用、保护线粒体功能、调控抗凋亡基因和抗氧化相关基因。对DJ-1进一步研究可能为氧化应激相关性疾病的预防和治疗提供新策略。
Oxidative stress involves the occurrence and development of a variety of diseases and the aging process of the human body. DJ-1 / PARK7 gene encodes DJ-1 protein, and it has been found that DJ-1 / PARK7 gene has a variety of biological functions including malignant transformation of cells, maturation and fertilization of male sperm, promotion of cell proliferation and resistance to oxidative stress. In recent years, the anti-oxidant function of DJ-1 has been paid more and more attention. Research levels include in vitro experiments, in vivo experiments and clinical studies. Its mechanism mainly includes its own configuration change, molecular chaperone function, protection of mitochondrial function, regulation of anti-apoptotic genes and antioxidant-related genes. Further research on DJ-1 may provide a new strategy for the prevention and treatment of oxidative stress-related diseases.