论文部分内容阅读
目的 研究新生儿感染患儿尿大分子碱性磷酸酶 (HMAP)的变化 ,为肾功能损害提供早期敏感的诊断方法。方法 利用抗HMAP的单克隆抗体 ,ELISA方法检测尿HMAP在感染组 (5 1例 )治疗前后的变化及在对照组 (3 6例 )的水平 ,并测定两组的尿 β2 微球蛋白 (β2 MG)和血清尿素氮 (BUN)、肌酐 (Cr)水平。结果 感染组治疗前尿HMAP、β2 MG水平显著高于治疗后和对照组 (P =0 0 0 0 1) ,感染组尿HMAP、β2 MG呈直线正相关(P <0 0 0 1) ,二者的异常发生率 (5 8 82 %和 74 5 1% )高于血清BUN、Cr(2 3 5 3 %和 3 3 3 3 % ) (P <0 0 1)。结论 感染新生儿常存在肾功能损害 ,尿HMAP可作为监测感染新生儿肾损害的早期诊断指标
Objective To study the change of urine alkaline phosphatase (HMAP) in children with neonatal infection and provide an early and sensitive diagnostic method for renal dysfunction. Methods The changes of urinary HMAP in the infected group (51 cases) and the control group (36 cases) were measured by anti-HMAP monoclonal antibody and ELISA. Urinary β2 microglobulin (β2 MG) and serum urea nitrogen (BUN) and creatinine (Cr) levels. Results The levels of HMAP and β2 MG in the infected group were significantly higher than those in the control group and the control group (P = 0.00001) The incidence of abnormalities (58 82% and 74 5 1%) was higher than that of serum BUN and Cr (23 35% and 33 33% respectively) (P 0 01). Conclusions Infected neonates often have renal dysfunction. Urinary HMAP can be used as an early diagnostic indicator to monitor neonatal renal damage