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目的 :探讨癌基因蛋白 p5 3、c- erb B- 2与乳腺癌组织学分级的关系。方法 :用免疫组织化学法(L SAB)检测 p5 3、c- erb B- 2癌基因蛋白在 40例乳腺癌的表达 ,并分析其与乳腺癌组织学分级的关系。采用 χ2检验进行统计学处理。结果 :p5 3、c- erb B- 2过度表达在乳腺癌 级、 级明显高于 级 ,各级间差异有显著性 (P<0 .0 1) ;40例乳腺癌两种癌基因蛋白共同表达者 2 1例 ,占 5 2 .5 % ,均为 级和 级。结论 :p5 3、c- erb B- 2与乳腺癌组织学分级有密切关系 ,是判断乳腺癌预后的重要指标 ;多个癌基因蛋白的表达异常及协同作用与乳腺癌生物学行为有一定的相关性
Objective: To investigate the relationship between oncogene protein p5 3, c-erb B-2 and histological grade of breast cancer. Methods: The expressions of p53 and c-erb B-2 oncoproteins in 40 cases of breast cancer were detected by immunohistochemistry (L SAB), and their relationship with the histological grade of breast cancer was analyzed. Using χ2 test for statistical analysis. Results: The overexpression of p5 3 and c-erb B-2 in breast cancer was significantly higher than that in grade, and there was significant difference among all grades (P <0.01). Forty cases of breast cancer with two oncogenes 21 cases of expression, accounting for 52.5%, are level and level. Conclusion: There is a close relationship between the expression of p53 and c-erb B-2 in histological grade of breast cancer, which is an important index to judge the prognosis of breast cancer. The abnormal expression of multiple oncoproteins and their synergistic effects have certain biological behaviors with breast cancer Correlation