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目的探讨血糖控制欠佳的2型糖尿病患者使用3种胰岛素类似物联合口服降糖药物的临床治疗效果。方法3组患者均给予口服二甲双胍药物治疗,A组同时给予甘精胰岛素注射液,B组同时给予预混人胰岛素30 R注射液,C组同时给予预混门冬胰岛素注射液。记录3组患者给药前后各时间段血糖变化情况,给予统计学分析。结果经治疗后3组患者各时间段血糖值均较治疗前明显下降,A组患者下降幅度更为明显,A组与B组、C组患者治疗后血糖值对比,差异有统计学意义(P<0.05)。结论临床医生应根据血糖控制欠佳的2型糖尿病患者实际情况,选择合适的胰岛素类似物联合口服降糖药物治疗方案,从而保障患者生活质量及生命安全。
Objective To investigate the clinical effect of 3 kinds of insulin analogue combined with oral hypoglycemic agents in type 2 diabetes patients with poorly controlled blood glucose. Methods 3 patients were given oral metformin drug treatment, group A given glargine injection, while group B was given pre-mixed insulin 30 R injection, while group C was given aspartic insulin injection. The changes of blood glucose in the three groups before and after administration were recorded, and statistical analysis was given. Results After treatment, the blood glucose of the three groups significantly decreased at each time point compared with that before treatment, and the decrease in group A was more obvious. The difference of blood glucose level between group A and group B and group C after treatment was statistically significant (P <0.05). Conclusions Clinicians should choose the appropriate insulin analogue combined with oral hypoglycemic drug therapy according to the actual conditions of type 2 diabetic patients with poorly controlled blood glucose so as to ensure the quality of life and safety of patients.