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目的：研究双相气道正压通气模式（ＢｉＰＡＰ）对急性肺损伤（ＡＬＩ）动物模型心肺功能的影响。方法：１１只犬麻醉后，用油酸造成ＡＬＩ模型。采用自身对照法比较其在ＢｉＰＡＰ、压力控制反比通气（ＰＣＩＲＶ）和容量控制反比通气（ＶＣＩＲＶ）３种通气模式中的呼吸、循环参数的变化。结果：在保持相同每分通气量和平均气道压的情况下，ＢｉＰＡＰ和ＰＣＩＲＶ模式的气道峰压均分别低于相同条件下ＶＣＩＲＶ模式的气道峰压，Ｐ均＜０．０５；在平均气道压相同情况下，ＢｉＰＡＰ和ＰＣＩＲＶ模式每分通气量分别为（４．４２±０．４３）Ｌ／ｍｉｎ和（４．４３±０．３９）Ｌ／ｍｉｎ，均大于ＶＣＩＲＶ模式的（３．８４±０．２０）Ｌ／ｍｉｎ和（３．７６±０．２３）Ｌ／ｍｉｎ，Ｐ均＜０．０５；ＢｉＰＡＰ模式时，肺泡死腔和肺内分流分别为（２０．２４±２．３６）和（１５．８０±２．６２），均较ＶＣＩＲＶ模式的（２４．９６±１．８７）和（２１．３６±２．２７）低（Ｐ均＜０．０５）；但ＰＣＩＲＶ模式时，上述两个指标与ＶＣＩＲＶ模式无显著性差异。结论：ＢｉＰＡＰ将压力控制通气和自主呼吸合为一体，是一种较好的治疗ＡＬＩ的通气模式。
Objective: To investigate the effect of biphasic positive airway pressure (BiPAP) on cardiopulmonary function in acute lung injury (ALI) animal model. METHODS: Eleven dogs were anesthetized with oleic acid to induce the ALI model. The changes of respiration and circulation parameters in BiPAP, PCIRV and VCIRV ventilation were compared by self-contrast method. Results: The peak airway pressures of BiPAP and PCIRV were lower than those of VCIRV under the same conditions with the same minute ventilation and mean airway pressure (P <0.05) Under the same mean airway pressure, the ventilation rates of BiPAP and PCIRV were (4.42 ± 0.43) L / min and (4.43 ± 0.39) L / min, respectively, which were higher than that of VCIRV model 3.84 ± 0.20) L / min and (3.76 ± 0.23) L / min respectively, all P <0.05. In the BiPAP model, the dead space of pulmonary alveolar and shunt of lung were (20.24 ± 2.36) and (15.80 ± 2.62), respectively, were lower than those of VCIRV (24.96 ± 1.87) and (21.36 ± 2.27) (P <0.05) PCIRV mode, the two indicators and the VCIRV mode no significant difference. Conclusion: BiPAP combines pressure-controlled ventilation and spontaneous breathing, which is a good ventilation model for ALI.