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近年来研究发现白细胞介素8对单核细胞有趋化作用,能促使单核细胞黏附于血管内皮,募捐中性粒细胞和淋巴细胞进入内皮下间隙,促进平滑肌细胞增生以及增加斑块的不稳定性,参与动脉粥样硬化的形成,在糖尿病大血管病变的发生和发展中起着重要的作用。糖尿病时的糖脂代谢紊乱、氧化损伤、肿瘤坏死因子及同型半胱氨酸水平升高等多种因素可导致白细胞介素8水平上升。
In recent years, it has been found that interleukin-8 has a chemotactic effect on monocytes, which can promote monocyte adhesion to vascular endothelium, donate neutrophils and lymphocytes into the subepithelial space, promote smooth muscle cell proliferation and increase plaque Stability, involved in the formation of atherosclerosis plays an important role in the development and progression of diabetic macroangiopathy. Various factors such as dyslipidemia, oxidative damage, elevated levels of tumor necrosis factor and homocysteine in diabetes can lead to elevated interleukin-8 levels.