论文部分内容阅读
目的探讨冠心病患者颈动脉内膜-中层厚度(IMT)及斑块与血清白细胞介素-18(IL-18)水平的临床相关性。方法126例经选择性冠状动脉造影检查的患者分为冠心病组及对照组,行颈动脉超声检查,测量IMT厚度并观察粥样斑块发生情况;在行冠状动脉造影前抽取股动脉血,测血清IL-18水平。结果冠心病患者颈动脉IMT[(0.93±0.26)mm]、斑块发生率[6.9%(3/43)]、IL-18的水平[(316.5±94.2)pg/ml]均较非冠心病患者的相应指标[(0.65±0.13)mm、97.65%(81/83)、6.9%(3/43)]明显增高(P<0.05)。结论颈动脉IMT、斑块发生率、血清IL-18水平的检测可作为定量检测冠状动脉粥样硬化(CAS)进而判断冠心病危险度的良好指标。
Objective To investigate the clinical significance of carotid intima - media thickness (IMT) and serum levels of interleukin - 18 (IL - 18) in patients with coronary heart disease. Methods One hundred and sixty-six patients undergoing selective coronary angiography were divided into coronary heart disease group and control group. Carotid ultrasonography was performed to measure the thickness of IMT and to observe the occurrence of atherosclerotic plaque. Before the coronary angiography, Serum IL-18 levels were measured. Results The carotid IMT (0.93 ± 0.26) mm, plaque incidence [6.9% (3/43)] and IL-18 levels (316.5 ± 94.2) pg / ml in patients with coronary heart disease were significantly higher than those without coronary heart disease The corresponding indexes of patients [(0.65 ± 0.13) mm, 97.65% (81/83), 6.9% (3/43)] were significantly higher (P <0.05). Conclusions The detection of carotid IMT, plaque incidence and serum IL-18 levels can be used as a good indicator for quantitative determination of coronary atherosclerosis (CAS) and coronary heart disease risk.