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目的观察人主要组织相容性抗原I(major histocompatibility complex,MHC-I)表达缺陷与维吾尔族妇女宫颈癌前病变进程的关系。方法收集维吾尔族妇女宫颈炎、宫颈内上皮瘤样病变(cervical intraepithelialneoplasia,CIN)和宫颈鳞癌患者的石蜡包埋组织标本共150例,采用免疫组织化学SP法检测MHC-I蛋白表达水平。结果 MHC-I抗原在慢性宫颈炎、CIN、宫颈鳞癌组织中阳性表达逐渐减少,其差异有统计学意义(P<0.001),并随着宫颈病变的进展呈下降趋势(r=-0.656,P<0.001);在宫颈上皮内瘤样病变中,MHC-I在宫颈上皮细胞表面表达逐渐减少,差异有统计学意义(P<0.01);MHC-I的表达与宫颈癌临床分期、病理分化程度、淋巴结转移密切相关。结论 MHC-I抗原的表达和异型细胞的恶性程度呈负相关趋势,表明MHC-I表达在宫颈上皮内瘤变和宫颈癌的发生、发展中可能起着重要的保护作用。
Objective To observe the relationship between the expression of human major histocompatibility complex (MHC-I) and the progression of cervical precancerous lesions in Uighur women. Methods A total of 150 Uyghur women with cervicitis, cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma were collected. Immunohistochemical SP method was used to detect the expression of MHC-I protein. Results The positive expression of MHC-I antigen in chronic cervicitis, CIN and cervical squamous cell carcinoma was decreased gradually (P <0.001) P <0.001). In cervical intraepithelial neoplasia, the expression of MHC-I on the surface of cervical epithelial cells gradually decreased, the difference was statistically significant (P <0.01); The expression of MHC-I was correlated with the clinical stage and pathological differentiation Degree, lymph node metastasis are closely related. Conclusions The expression of MHC-I antigen is negatively correlated with the malignant degree of dysplastic cells, indicating that MHC-I expression may play an important role in the development of cervical intraepithelial neoplasia and cervical intraepithelial neoplasia.