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目的：观察苦参碱口服后对肝损伤动物和肝炎病人的治疗作用。方法：给ＡＮＩＴ肝损伤小鼠灌胃治疗，比较给药与对照组的ＡＬＴ、ＡＳＴ、结合胆红素、总胆红素等指标，并取肝脏作病理检查。临床用苦参碱胶囊分别对急性黄疸型肝炎和慢性乙肝治疗４周和３个月。结果：苦参碱１００、１５０ｍｇ／ｋｇｉｇ３天能明显降低小鼠黄疸发生率，ＡＬＴ、ＡＳＴ、胆红素均明显下降，病理结果治疗组的肝损伤程度明显轻于对照组。４１例急性黄疸性肝炎经治疗后，７６．２％的病人ＡＬＴ于４周内恢复正常，１００％病人黄疸全部消除。３１例慢性乙肝病人中有３８．７％ＨＢｅＡｇ转阴，三项指标同时转阴者占１２．９％。结论：苦参碱口服对肝损伤小鼠治疗有效，对临床急、慢性肝炎均有较好的治疗效果。
Objective: To observe the curative effect of matrine after oral administration on liver injured animals and hepatitis patients. Methods: The mice with ANIT liver injury were treated by intragastric administration. ALT, AST, bilirubin and total bilirubin were compared between the administration and the control group, and the liver was taken for pathological examination. Clinical matrine capsules for acute jaundice hepatitis and chronic hepatitis B treatment for 4 weeks and 3 months. Results: Matrine 100,150mg / kgig3 days can significantly reduce the incidence of jaundice in mice, ALT, AST, bilirubin were significantly decreased, the pathological results of the treatment group, liver injury was significantly lighter than the control group. 41 cases of acute jaundice hepatitis after treatment, 76.2% of patients with ALT returned to normal within 4 weeks, 100% of patients were completely eliminated jaundice. Of the 31 patients with chronic hepatitis B, 38.7% had negative HBeAg, and 12.9% of those who passed the three indicators simultaneously. Conclusion: Oral administration of matrine is effective in treating liver injury in mice and has good therapeutic effect on acute and chronic hepatitis.