近年来国内报道斑蝥素治疗肝癌有一定疗效,且不降低周围血象中的白细胞,但对泌尿系统有不良反应。作者根据国外报道一些双环庚烷亚胺类化合物有较强的生理活性,且毒性较低,因而改变斑蝥素(Ⅰ)的结构,合成了Ⅱ、Ⅲ、Ⅳ、Ⅴ 4个类型31个亚胺化合物。希望保留其抗癌活性,克服其副作用。以上化合物经动物抗肿瘤筛选,发现三个化合物 In recent years, domestic reports of cantharidin treatment of liver cancer have a certain effect, and does not reduce the peripheral blood leukocytes, but the urinary system has adverse reactions. According to the foreign reports of some bicycloheptane imines have strong physiological activity, and low toxicity, thus changing the structure of cantharidin (Ⅰ), the synthesis of Ⅱ, Ⅲ, Ⅳ, Ⅴ 4 types of 31 imines Compound. Want to retain its anti-cancer activity, to overcome its side effects. The above compounds were screened by animal antitumor and three compounds were found