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变应性疾病的发生与许多细胞因子有关,以血清中IgEI、L-4I、L-5水平显著升高为特点。发作时细胞因子的产生及炎性介质的参与均与机体异常的免疫调节有关,即存在T辅助细胞亚群功能失调,通过释放细胞因子促进IgE的合成与分泌,并增加炎性细胞的浸润和活化。细胞因子网络失调可能是变应性疾病发生的分子生物学基础之一。白介素4(IL-4)是最强的IgE调节因子,其生物学功能均通过效应细胞表面IL-4受体介导。鉴于IL-4及其受体(IL-4R)在IL-4信号传导过程中的关键地位,IL-4及IL-4R基因被列为变态反应性疾病的重要候选基因,在它们的基因编码区段存在多个多态性位点,其中某些位点的多态性与变应性疾病相关。
The occurrence of allergic diseases and many cytokines, with serum IgEI, L-4I, L-5 levels were significantly increased. Occurrence of cytokines and inflammatory mediators involved in the abnormal immune regulation of the body that there is T helper cell subsets dysfunction by releasing cytokines to promote the synthesis and secretion of IgE and increased inflammatory cell infiltration and activation. Cytokine network disorders may be one of the molecular biological basis for the development of allergic diseases. Interleukin-4 (IL-4) is the strongest IgE regulator and its biological functions are mediated through IL-4 receptors on effector cells. Given the pivotal role of IL-4 and its receptor (IL-4R) in IL-4 signaling, the IL-4 and IL-4R genes are among the most important candidate genes for allergic diseases and are encoded by their genes There are multiple polymorphic loci in the section, some of which polymorphisms associated with allergic diseases.