蛋白C(PC)是由肝脏合成的维生素K依赖性抗凝血因子。作用通过典型的临床表现,以及用Laurell电免疫法测定PC抗原;用氯化钡吸附血浆中酶原,以凝血酶-血栓调节蛋白复合物激活,与合成底物孵育法测定PC活性;用产色法定量抗凝血酶Ⅲ(AT-Ⅲ)意外地遇见了8例内脏静脉血栓形成病人。其中2例以前患有血管血栓症.8例病人的PC活性和抗原量都明显降低。其中6例AT-Ⅲ活性也降低。这些患者伴有PC和AT-Ⅲ缺乏可能是由于血栓形成刺激物,如淤滞、改变激素,肝脏清除凝血活性物质机能 Protein C (PC) is a vitamin K-dependent anti-clotting factor synthesized by the liver. The role of the typical clinical manifestations, as well as by Laurell’s method for the determination of PC antigen; barium chloride adsorption of plasma prolactin, thrombin - thrombomodulin complex activation, incubation with synthetic substrate determination of PC activity; Colorimetric quantification of antithrombin III (AT-III) unexpectedly met 8 patients with visceral venous thrombosis. Two of the patients had previous vascular thrombosis, and the activity and antigenic amounts of PC in the eight patients were significantly lower. 6 cases of AT-III activity is also reduced. These patients with PC and AT-III deficiency may be due to thrombotic stimuli, such as stasis, changes in hormones, liver clearing clotting active substance function