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目的探讨克罗恩病(CD)患者肠道菌群结构的变化及与血沉(BS)、C反应蛋白(CRP)和TNF-α的关系。方法将150例我科收治的腹痛低热患者分为CD组(n=56)和非CD组(n=94),另选取30例健康者组成对照组,检查3组样本肠道菌群结构的变化及BS、CRP和TNF-α水平并分析其与肠道菌群结构的变化的关系。结果与对照组比较,非CD患者肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌的数量则显著下降,CD病组肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌和小梭菌的数量则显著下降,CD组和非CD组患者BS、CRP和TNF-α水平均增加,与非CD组比较,CD组BS、CRP和TNF-α水平均增加,随着患者BS、CRP和TNF-α水平的提高,CD组的肠球菌数量与非CD组的酵母菌数量均增加(P<0.05)。结论 CD患者肠道菌群结构的变化与BS、CRP和TNF-α水平及真菌减少相关。
Objective To investigate the changes of intestinal microflora in patients with Crohn’s disease (CD) and its relationship with serum creatinine (BS), C-reactive protein (CRP) and TNF-α. Methods One hundred and fifty patients with abdominal pain who were admitted to our department were divided into CD group (n = 56) and non-CD group (n = 94). 30 healthy people were selected as the control group to examine the intestinal flora structure Changes and the levels of BS, CRP and TNF-α were analyzed and their relationships with changes in intestinal flora were analyzed. Results Compared with the control group, the numbers of Enterobacteriaceae, Saccharomyces, Bacteroidetes and other bacteria increased but the numbers of eubacteria decreased significantly in non-CD patients. The numbers of Enterobacteriaceae, Saccharomyces, Bacteroidetes and other bacteria in CD patients increased The numbers of eubacterium and Clostridium were significantly decreased, the levels of BS, CRP and TNF-α in both CD and non-CD groups were increased, and the levels of BS, CRP and TNF-α in CD group were increased compared with non-CD group Patients with BS, CRP and TNF-α levels increased in the CD group of enterococci and non-CD group of yeast were increased (P <0.05). Conclusion The changes of intestinal microflora in CD patients are related to the levels of BS, CRP and TNF-α and the decrease of fungi.