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基因功能与表达模式异常是癌症的主要特征.日益增多的研究表明,DNA甲基化(DNAmethylation)、组蛋白修饰(histone modification)、染色质重塑(chromatin remodeling)以及microRNAs介导的基因沉默等表观遗传调控方式的异常与癌症的发生发展密切相关.阐明癌症发生发展过程中的表观遗传学调控改变并籍此设计、开发治疗癌症的有效药物已受到高度重视.本文综述了癌症表观调控研究领域的相关进展,并着重讨论了应用表观遗传调控的方法治疗癌症的现状和前景.
Abnormalities in gene function and expression patterns are the major hallmarks of cancer, and increasing numbers of studies show that DNA methylation, histone modification, chromatin remodeling, and microRNAs-mediated gene silencing The abnormality of epigenetic regulation is closely related to the occurrence and development of cancer.To clarify the changes of epigenetic regulation during the development of cancer and to design and develop effective drugs for the treatment of cancer have attracted great attention.This paper reviews the expression of cancer Regulation and control research in the field of progress, and focused on the application of epigenetic regulation of the treatment of cancer status and prospects.