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目的 观察去甲长春花碱为主的联合化疗方案治疗晚期乳腺癌的近期疗效和毒性反应。方法 NVB40mg/m~2、d_(1、8)iv,联合DDP40mg/m~2,d_(1～3)ivg~(tt),联合FT—207 1.0g/m~2,d_(1～5)ivg~(tt),联合EADM30mg/m~2,d_(1、8)iv,5—Fu500mg/m~2,d_(1、8)ivg~(tt),21天为1个周期,治疗2个周期。结果 30例病人CR3例,PR19例,PD3例,NC5例,有效率73.7％。NF、NEF、NP方案的有效率分别为68.7％、50％、50％,三种方案差异无显著性,NVB能使肿块缩小,缓解症状,尤其对软组织转移灶疗效较好。主要毒性反应为骨髓抑制和局部静脉炎。结论 NVB联合化疗是治疗晚期乳腺癌的最有效药物。
Objective To observe the short-term curative effect and toxicity of norepinephrine-based combination chemotherapy for advanced breast cancer. Methods NVB 40mg/m~2, d_(1,8)iv, combined DDP40mg/m~2, d_(1~3)ivg~(tt), combined FT-207 1.0g/m~2, d_(1~5 Ivg~(tt), combined EADM 30mg/m~2, d_(l,8)iv, 5-Fu500mg/m~2, d_(l,8)ivg~(tt), 21 days for 1 cycle, treatment 2 cycles. Results There were 3 cases of CR, 19 cases of PR, 3 cases of PD, and 5 cases of NC. The effective rate was 73.7%. The effective rates of NF, NEF, and NP regimens were 68.7%, 50%, and 50%, respectively. There was no significant difference between the three regimens. NVB can shrink the tumor and relieve symptoms, especially for soft tissue metastases. The main toxicities were myelosuppression and local phlebitis. Conclusion NVB combined with chemotherapy is the most effective drug for the treatment of advanced breast cancer.