Since the General Channel designed for the South-to-North Water Transfer Project in China has to cross many rivers and streams flowing from west to east, there are potentially serious effects additional flooding on the westem side of the project alignment. Therefore, a 2-D numerical model for forecasting basin flood disasters was established and verified using historical flood data. The model was applied to researching the interaction between the proposed Project and flooding events for 5 streams in the Anyang River reach as a representative case study. Simulated results indicate that the model could correctly forecast the flood, submerged area and depths, and water surface elevations along the left side of the channel. The discharge capacity and location of hydraulic structures in the transfer canal alignment were analyzed. Then adjustments to the dimensions and positioning of proposed hydraulic structures were recommended at intersections, especially the addition of a channel to transfer flood water from one stream to another, which can effectively limit the sluice and protect the Anyang City from flooding.