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运动乳剂(YDE)系一中药复方制剂,本文就其镇痛及抗炎作用进行了研究.在小鼠热板模型上,YDE150、300mg·kg~(-1)足掌注射可显著延长小鼠舔足潜伏期;在小鼠扭体模型上,YDE300、600mg·kg~(-1)可显著降低小鼠扭体数;在小鼠福尔马林试验上,足掌涂敷YDE180、360mg·kg~(-1)可显著降低疼痛评分,YDE300·mg·kg~(-1)可显著抑制二甲苯致小鼠耳肿胀和大鼠皮下肉芽肿的形成.实验结果表明YDE有一定的镇痛和抗炎作用,并且局部应用有效.
The sports emulsion (YDE) is a traditional Chinese medicine compound preparation. This article has studied its analgesic and anti-inflammatory effects. On mouse hot plate model, YDE150, 300mg·kg -1 paw injection can significantly prolong mice Latent period of lameness; on mouse writhing model, YDE300, 600 mg·kg -1 can significantly reduce the number of writhing of mice; in mouse formalin test, paw palm coating with YDE180, 360 mg·kg ~(-1) significantly reduced the pain score. YDE300·mg·kg -1 significantly inhibited xylene-induced ear swelling and subcutaneous granuloma formation in rats. Experimental results showed that YDE had certain analgesia and Anti-inflammatory effect, and local application is effective.