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目的了解胃粘膜异型增生形态与ｐ５３，ｂｃｌ２和ｃｅｒｂＢ２表达的关系．方法胃粘膜炎症性增生４５例，异型增生４４例和胃腺癌３０例，胃粘膜活检标本进行组织形态观察，并采用ＳＰ免疫组化法，观察ｐ５３，ｂｃｌ２和ｃｅｒｂＢ２基因表达．结果异型增生病灶，小者仅有单个腺管，多者达１０余个腺管，多数３个～５个腺管．异型腺管有不同程度的扩张，为圆形或不规则形，腺上皮细胞单层或复层排列．核大小不等，染色质粗，核形态不一，为圆形、椭圆形或不规则形，可见核仁或核分裂．异型增生的腺管与周围的腺管分界清，这种现象称之为胃粘膜腺管区域性异型增生．异型增生腺管ｐ５３，ｂｃｌ２和ｃｅｒｂＢ２基因蛋白表达分别为９１％，７２７％和３８６％．结论胃粘膜腺管区域性异型增生与胃腺癌关系密切．
Objective To investigate the relationship between the morphology of gastric dysplasia and the expression of p53, bcl2 and cerbB2. Methods 45 cases of inflammatory hyperplasia of gastric mucosa, 44 cases of dysplasia and 30 cases of gastric adenocarcinoma were performed. The biopsy specimens of gastric mucosa were observed for histomorphology. S-P immunohistochemistry was used to observe p53, bcl-2 and c-erbB-2. gene expression. The results of dysplasia lesions, the only small single gland, more than 10 glands, most of the 3 ~ 5 glands. Different-shaped glandular ducts have different degrees of expansion, round or irregular, glandular epithelial cells arranged in a single layer or multiple layers. The size of the nucleus varies, and the chromatin is coarse, and the nucleus is of different shapes. It is round, oval, or irregular, showing nucleoli or mitosis. Abnormal hyperplasia of the gland and the surrounding glands clear the border, this phenomenon is called gastric mucosal glandular regional dysplasia. The expression of p53, bcl2 and cerbB2 genes in dysplasia glands were 9.1%, 72.7% and 38.6%, respectively. 4. Conclusion The gastric mucosal glandular regional dysplasia is closely related to gastric adenocarcinoma.