论文部分内容阅读
4′-甲基-7-(2-羟基-3-异丙胺基丙氧基)-黄酮盐酸盐(SIPI-549)对大鼠和家兔实验性血栓形成有剂量(或浓度)依赖性的抑制作用。ⅳ7.5～20.0 mg/kg,使大鼠颈动—静脉旁路血栓湿重减轻。家兔半体内试验(ⅳSIPI-549 10 mg/kg),可使Chandler管中的雪暴现象出现时间和血栓形成时间延长,血栓湿重和干重减轻。家兔体外实验与半体内试验的结果基本一致。
Dose (or concentration) dependence of 4’-methyl-7- (2-hydroxy-3- isopropylaminopropoxy) -flavone hydrochloride (SIPI- 549) on experimental thrombosis in rats and rabbits Inhibition. Ⅳ 7.5 ~ 20.0 mg / kg, so that rat carotid - venous bypass thrombosis wet weight loss. A semi-in vivo test (ⅳ SIPI-549 10 mg / kg) in rabbits prolonged the onset of snowstorms and prolonged thrombosis in Chandler tubes with reduced thrombus wet weight and dry weight. Rabbit in vitro and in vivo test results are basically the same.