子痫前期(pre-eclampsia,PE)是妊娠期特有的疾病,发生率高达8%,常伴有严重的母婴并发症,其中早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)为起病于孕34周前的重度子痫前期,占重度子痫前期发病的20.4%[1]。本研究采用代谢组学技术来研究不同氧浓度下正常妊娠孕妇及早发型重度子痫前期患者胎盘绒毛组织培养液中代谢足迹的变化,进一步了解早发型重度子痫前期的发病机制。 Pre-eclampsia (PE) is a peculiar disease of pregnancy, the incidence rate is as high as 8%, often accompanied by serious maternal and infant complications, including early onset severe pre-eclampsia (EOSP) For the onset of pregnancy 34 weeks before severe preeclampsia, severe preeclampsia incidence of 20.4% [1]. Metabolomics was used to study the metabolic changes of placental tissue in normal pregnant women and early-onset severe preeclampsia patients under different oxygen concentrations to further understand the pathogenesis of early-onset severe preeclampsia.