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系统性红斑狼疮(SLE)临床过程多变,难于估价疗效。环磷酰胺与类固醇合用治疗本病已20多年,有认为前者可减少后者的用量,但毒性很大。本文报告2例女性患者长期应用环磷酰胺治疗后发生膀胱癌。例1为28岁女性,于1969年暴晒阳光后发生SLE,临床症状有皮疹、溶血性贫血和蛋白尿。肾活检显示增殖性肾小球肾炎。开始用类固醇及环磷酰胺50～100mg/d 治疗,后者在6年内间歇使用。1981年患者出现泌尿道感染症状,培养无菌,
Systemic lupus erythematosus (SLE) changes in the clinical course, difficult to evaluate the efficacy. Cyclophosphamide and steroids combined treatment of the disease has been 20 years, there is that the former can reduce the latter’s dosage, but a great deal of toxicity. This article reports two cases of female patients with bladder cancer after long-term use of cyclophosphamide. Example 1 A 28-year-old woman developed SLE after sun exposure in 1969 with rash, hemolytic anemia and proteinuria on her clinical symptoms. Renal biopsy showed proliferative glomerulonephritis. Start with steroids and cyclophosphamide 50 ~ 100mg / d treatment, which is intermittent use within 6 years. In 1981, patients showed symptoms of urinary tract infection, sterile,