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目的:探讨干预前后骨科围术期抗菌药物预防应用情况。方法:2013年5月对缙云县第二人民医院骨科手术治疗的围术期抗菌药物预防性用药情况采取干预措施,干预前后各选取90例患者临床资料进行回顾性分析,观察比较两组患者用药时间、住院时间、住院费用、用药品种、联合用药情况、不合理用药情况差异。结果:干预组术前2小时内用药患者数较对照组明显增加,>2小时用药明显降低,术后≤72小时用药患者明显增加(P<0.05);干预组患者住院时间和住院费用均明显低于对照组患者(P<0.05);对照组患者抗菌药物以三代头孢菌素类药物为主,干预后以二代头孢菌素类药物为主;干预组单用抗菌药物患者较对照组明显增加,联合用药显著下降(P<0.05);干预后抗菌药物用药不合理情况较对照组患者明显改善(P<0.05)。结论:针对骨科围术期抗菌药物预防用药采取干预措施,可明显缩短用药时间和住院时间,联合用药趋于合理,不合理用药明显改善。
Objective: To investigate the prevention and treatment of antimicrobial agents during orthopedic surgery before and after intervention. Methods: In May 2013, interventions were carried out on the prophylactic use of perioperative antibiotics in the orthopedic surgery of Second People’s Hospital of Jinyun County. The clinical data of 90 patients before and after the intervention were analyzed retrospectively. The patients in both groups were compared Time, length of hospital stay, hospitalization expenses, medication variety, combination medication, irrational medication use. Results: The number of patients in the intervention group was significantly higher than that in the control group within 2 hours before operation, the dosage was significantly reduced in> 2 hours, and the dosage in patients ≤72 hours after operation was significantly increased (P <0.05). The hospitalization cost and hospitalization cost were significantly higher in the intervention group (P <0.05). In the control group, the third generation cephalosporins were the main antibacterial drugs, and the second generation cephalosporins were the main ones in the control group. The patients in the intervention group were significantly better than the control group (P <0.05). The unreasonable use of antibacterials in the intervention group was significantly improved compared with the control group (P <0.05). Conclusion: The interventions for antimicrobial prophylaxis during orthopedic surgery can significantly shorten the time of medication and hospital stay, and the combination therapy tends to be reasonable and the unreasonable medication significantly improves.