心肌纤维化(myocardial fibrosis,MF)是指心肌细胞外基质中胶原纤维过量积聚、胶原浓度显著升高或成分发生改变,它在多种心血管疾病中普遍存在,是心肌对压力超负荷、炎症反应、氧化应激等的反应,多种细胞因子参与其中,MF是心肌重构的一部分,导致心脏舒张功能与收缩功能下降,心力衰竭的发生。目前,多项研究证实众多炎症因子在MF的进展过程中起重要作用,本文结合国内外研究进展,对主要炎症因子在MF中的作用进行综述。 Myocardial fibrosis (MF) refers to excessive accumulation of collagen fibers in cardiac extracellular matrix, collagen concentration was significantly increased or changes in composition, it is common in many cardiovascular diseases, myocardial overload, inflammation Response, oxidative stress and other reactions, a variety of cytokines involved, MF is part of myocardial remodeling, leading to decreased diastolic function and systolic function, heart failure. At present, a number of studies have confirmed that many inflammatory cytokines play an important role in the progression of MF. In this review, we reviewed the roles of major inflammatory cytokines in MF.