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目的:探讨原发性宫颈小细胞癌(SCCC)的临床病理特征、免疫组化特点及鉴别诊断。方法对1例宫颈小细胞癌进行组织病理学观察、免疫组化检测和文献复习。结果:组织学显示为3种不同分化的细胞区域,小细胞区肿瘤细胞小而圆,胞质少,核染色质深,核仁不明显,分裂相活跃,可见坏死,肿瘤细胞呈片状浸润;合并鳞癌及腺癌分化。免疫组化:小细胞癌CK、NSE和Syn(+),CgA和LCA(-);腺癌CEA(+)。结论:宫颈小细胞癌是一种少见的高度恶性肿瘤,具有特征性的形态学改变,应与宫颈的小细胞鳞状细胞癌、淋巴瘤、肺转移性小细胞癌、胚胎性横纹肌肉瘤、宫内膜间质肉瘤等进行鉴别。
Objective: To investigate the clinicopathologic features, immunohistochemical features and differential diagnosis of primary small cell carcinoma of the cervix (SCCC). Methods One case of small cell carcinoma of the cervix was observed by histopathology, immunohistochemistry and literature review. Results: Histologically, there were three different differentiated cell regions. The small cell area had small and round tumor cells, few cytoplasm, deep chromatin, no clear nucleolus, active dividing nuclei and necrosis. The tumor cells showed flake infiltration ; Combined squamous cell carcinoma and adenocarcinoma differentiation. Immunohistochemistry: Small cell carcinoma CK, NSE and Syn (+), CgA and LCA (-); Adenocarcinoma CEA (+). Conclusion: Small cell carcinoma of the cervix is a rare and highly malignant tumor with characteristic morphological changes. It should be associated with small cell squamous cell carcinoma of the cervix, lymphoma, small cell lung metastasis of lung, embryonal rhabdomyosarcoma, Endometrial stromal sarcoma and other identification.