论文部分内容阅读
关于前列腺素在排卵中作用,虽然已得到实验证明,但在卵泡破裂中的作用尚未弄清。为了明确前列腺素在卵泡破裂中的作用机理,应用前列腺素合成抑制剂消炎痛(indomethacin),研究各种条件下对幼鼠诱发排卵反应的影响。对22日龄的幼鼠先皮下注射孕马血清促性腺激素5 U,56小时后静脉注射人绒毛膜促性腺激素10U。在18小时后计算输卵管内的卵子数,以平均排卵数来评价排卵反应。结果如下: (1)各种剂量的消炎痛与人绒毛膜促性腺激素同时给予时,平均排卵数随用量增加而减少,消炎痛给予90μg以上时排卵反应完全抑制。 (2)以上法得知消炎痛最小有效量为90μg,
On the role of prostaglandins in ovulation, although it has been experimentally proven, but the role of follicular rupture has not yet been clarified. In order to clarify the mechanism of action of prostaglandins in follicular rupture, the prostaglandin synthesis inhibitor indomethacin was used to study the effect on ovulation induction induced by various conditions in young rats. 22-day-old pups were injected subcutaneously with 5 ug of pregnant mare serum gonadotropin and intravenously injected with 10 U of human chorionic gonadotropin 56 hours later. The number of eggs in the fallopian tube was calculated after 18 hours, and the ovulation response was evaluated by the average number of ovulation. The results are as follows: (1) When different doses of indomethacin and human chorionic gonadotropin were given at the same time, the average number of ovulation decreased with the increase of dosage. The ovulation reaction was completely inhibited when indomethacin was given above 90μg. (2) The above method that indomethacin minimum effective amount of 90μg,