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目的分析宫内感染与早产儿脑损伤相关性,为早期诊断治疗提供参考。方法选取产科2015年1月-12月分娩早产儿170例为研究对象,对早产儿孕母检测绒毛膜羊膜炎,判断是否存在宫内感染。早产儿行头颅CT检查确定是否存在脑损伤,分为脑损伤组52例和非脑损伤组118例,采用酶联免疫吸附法测定脐带血各个指标,并检测新生儿出生后C-反应蛋白含量,比较各组生化指标差异。结果早产儿脑损伤组患儿孕母宫内感染率(61.5%)显著高于非脑损伤组(30.5%)(P<0.05),出生1天新生儿脑损伤患者CRP(1.72±6.73)mmol/L显著高于非脑损伤组(0.71±0.24)mmol/L(P<0.05),两组新生儿白细胞计数无明显差异;脑损伤组患儿IL-1β(6.52±2.39)ρ·μg·L~(-1)、IL-6(7.96±4.29)ρ·μg·L~(-1)、TNF-α水平(5.46±1.28)ρ·μg·L~(-1)显著高于非脑损伤组IL-1β(1.52±1.28)ρ·μg·L~(-1)、IL-6(1.62±0.27)ρ·μg·L~(-1)、TNF-α水平(3.26±0.74)ρ·μg·L~(-1)(P<0.05),脑损伤组患儿IL-10水平(1.20±0.26)ρ·μg·L~(-1)显著高于非脑损伤组患儿(1.59±0.28)ρ·μg·L~(-1)(P<0.05)。结论宫内感染早产儿更加容易出现脑损伤,母体怀孕期间需要定期产检,避免宫内感染出现。
Objective To analyze the correlation between intrauterine infection and brain injury in premature infants and provide reference for early diagnosis and treatment. Methods 170 cases of preterm infants delivered from January to December 2015 in obstetrics were selected as research objects. Chorioamnionitis was detected in pregnant women of premature infants to determine whether there was intrauterine infection. Preterm children underwent craniocerebral CT examination to determine the existence of brain injury, divided into brain injury group of 52 patients and 118 cases of non-brain injury group, the use of enzyme-linked immunosorbent assay cord blood indicators, and detection of neonatal postpartum C-reactive protein content , The differences of biochemical indexes of each group were compared. Results The intrauterine infection rate (61.5%) in preterm infants with brain injury group was significantly higher than that in non-brain injury group (30.5%) (P <0.05). The CRP (1.72 ± 6.73) mmol / / L was significantly higher than that in the non-brain injury group (0.71 ± 0.24) mmol / L (P <0.05). There was no significant difference in neonatal white blood cell count between the two groups. IL-1β (6.52 ± 2.39) The levels of IL-6 (7.96 ± 4.29) ρ · μg · L -1, TNF-α (5.46 ± 1.28) ρ · μg · L -1 were significantly higher than those of non-brain IL-1β (1.52 ± 1.28) ρ · μg · L -1, IL-6 (1.62 ± 0.27) ρ · μg · L -1 and TNF-α level (3.26 ± 0.74) ρ The level of IL-10 in the brain injury group (1.20 ± 0.26) ρ · μg · L -1 was significantly higher than that in the non-brain injury group (1.59) · μg · L -1 (P <0.05) ± 0.28) ρ · μg · L -1 (P <0.05). Conclusion Intrauterine infection of premature children is more prone to brain injury, the need for regular maternal pregnancy test, to avoid intrauterine infection.