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目的探讨血清降钙素原(procalcitonin,PCT)在鉴别儿童细菌性肺炎、支原体肺炎与病毒性肺炎感染中的作用。方法利用电化学发光免疫测定法对143例社区获得性肺炎的住院患儿(其中支原体肺炎组53例、病毒性肺炎组65例、细菌性肺炎组25例)进行PCT检测,并同时对C-反应蛋白(CRP)和白细胞(WBC)进行联合分析。结果细菌性肺炎组的PCT值(0.102μg/L)明显高于支原体肺炎组(0.076μg/L)和病毒性肺炎组(0.065μg/L),差异均有统计学意义(P<0.05);而支原体肺炎组和病毒性肺炎组的PCT值差异无统计学意义(P>0.05)。结论 CAP患儿血清PCT检测对早期诊断细菌性肺炎有重要意义,是一种优于WBC与CRP的敏感指标。
Objective To investigate the role of serum procalcitonin (PCT) in the identification of bacterial pneumonia, mycoplasma pneumonia and viral pneumonia in children. Methods Electrochemiluminescence immunoassay was used to detect PCT in 143 hospitalized children with community-acquired pneumonia (53 in mycoplasma pneumonia group, 65 in viral pneumonia group and 25 in bacterial pneumonia group) Reactive protein (CRP) and white blood cells (WBC) for joint analysis. Results The PCT value (0.102 μg / L) in bacterial pneumonia group was significantly higher than that in mycoplasma pneumonia group (0.076 μg / L) and viral pneumonia group (0.065 μg / L) (P <0.05). There was no significant difference in PCT value between mycoplasma pneumonia group and viral pneumonia group (P> 0.05). Conclusions Serum PCT in children with CAP is of great significance for the early diagnosis of bacterial pneumonia and is a sensitive indicator of WBC and CRP.