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Sensors capable of recognizing cell surface carbohydrates,such as sialyl Lewis X(sLe~x),are invaluable research tools and for the diagnosis and early detection of many forms of cancer.In this paper,we report the design and synthesis of a series of bisboronic acids 6(a-f) as fluorescent sensors towards mono-/oligosaccharides.Among them,compounds 6d and 6e showed strong binding affinities with glucose and fructose,while compound 6c,in which two anthracene-based boronic acid units were linked by a hexamethylene spacer,was able to recognize sLe~x selectivity and stained HEPG2 cells at 1 μmoI/L.
Sensors capable of recognizing cell surface carbohydrates, such as sialyl Lewis X (sLe ~ x), are invaluable research tools and for the diagnosis and early detection of many forms of cancer. In this paper, we report the design and synthesis of a series of Bisboronic acids 6 (af) as fluorescent sensors towards mono- / oligosaccharides. Among them, compounds 6d and 6e showed strong binding affinities with glucose and fructose, while compound 6c, in which two anthracene-based boronic acid units were linked by a hexamethylene spacer , was able to recognize sLe ~ x selectivity and stained HEPG2 cells at 1 μmoI / L.