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目的:考察接活跌打膏的抗炎及镇痛作用。方法:采用角叉菜胶致大鼠足趾肿胀法、棉球致大鼠肉芽肿法观察接活跌打膏的抗炎作用;小鼠热板法和小鼠醋酸扭体法观察接活跌打膏的镇痛作用。结果:和模型组比较,在给药后2 h,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组可显著抑制角叉菜胶致大鼠足趾肿胀(P<0.05);和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能抑制大鼠棉球肉芽组织干重(P<0.05);和正常对照组比较,接活跌打膏28 g·kg-1和14 g·kg-1药材剂量组能显著减少醋酸引起的小鼠扭体反应次数,在给药后60 min,能延长小鼠热板痛阈值(P<0.05或P<0.01)。结论:接活跌打膏具有显著的抗炎和镇痛作用。
OBJECTIVE: To investigate the anti-inflammatory and analgesic effects of live drop cream. Methods: Carrageenan caused by rat toe swelling method, cotton ball granuloma caused by granulation method to observe the anti-inflammatory effect of live drop cream; mouse hot plate method and mouse acetic acid writhing method to observe the live drop Paste the analgesic effect. Results: Compared with the model group, the dose of 28g · kg-1 and 14g · kg-1 of Beidao cream 2 h after injection significantly inhibited carrageenan-induced rat toe swelling (P <0.05) .Compared with the normal control group, the dosage of 28g · kg-1 and 14g · kg-1 of Benda cream can inhibit the dry weight of granulation tissue in cotton ball (P <0.05), and the normal control Compared with the control group, the doses of 28 g · kg-1 and 14 g · kg-1 of Bentong Paste can significantly reduce the number of writhing reactions induced by acetic acid in mice, which can prolong the number of mice hot plate after 60 min Pain threshold (P <0.05 or P <0.01). Conclusion: Active drop cream has significant anti-inflammatory and analgesic effects.