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目的:探讨髓外浆细胞瘤的临床特点诊疗手段。方法:对1995年1月至2013年12月在本科室收治的18例髓外浆细胞瘤进行回顾性分析,其中单纯放射治疗2例(11.7%),综合治疗15例(83.3%),单纯手术1例(5.6%)。结果:中位随访71个月(5~263个月),2例(11.7%)局部复发,3例(16.7%)转化为多发性骨髓瘤,单纯手术或放射治疗5年生存率为0,综合治疗的3、5、10年生存率分别为83.3%(15/18)、77.8%(7/9)、71.4%、(5/7)。结论:综合治疗髓外浆细胞瘤可获得良好的局部控制率和长期生存率,部分髓外浆细胞瘤可向多发性骨髓瘤转化,故需密切观察。
Objective: To explore the clinical features of extramedullary plasmacytoma diagnosis and treatment. Methods: Eighteen patients with extramedullary plasmacytoma treated in our department from January 1995 to December 2013 were retrospectively analyzed. Among them, 2 cases (11.7%) were treated by radiotherapy alone, 15 cases (83.3%) were treated by simple radiotherapy, Surgery in 1 case (5.6%). Results: The median follow-up was 71 months (range 5 to 263 months), 2 cases (11.7%) were locally recurred and 3 cases (16.7%) were converted to multiple myeloma. The 5-year survival rate of surgery or radiotherapy alone was 0, The 3-, 5-, 10-year survival rates of combined therapy were 83.3% (15/18), 77.8% (7/9), 71.4%, (5/7), respectively. CONCLUSIONS: Good local control rate and long-term survival rate can be obtained by comprehensive treatment of extramedullary plasmacytoma. Some extramedullary plasmacytomas can be transformed into multiple myeloma, so close observation is needed.