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为探讨小儿丙型肝炎（简称丙肝）临床及免疫病理改变相互间的关系，对８例小儿丙型肝炎在进行临床、病理及超微病理研究的基础上，应用抗丙型肝炎病毒Ｃ３３ｃ２Ｂ６株单克隆抗体，对其肝脏做相应丙肝抗原（ＨＣＡｇ）的检测。结果表明，肝脏ＨＣＡｇ检出率较高（８／８例），但阳性细胞数明显低于成人。阳性产物多定位于胞浆内。同期检测血清抗ＨＣＶ和ＨＣＶＲＮＡ，阳性率各为５０％（４／８例）。提示肝脏免疫病理与超微病理改变无相关性。肝脏ＨＣＡｇ阳性细胞数少者较多者似肝功异常及病理改变重、预后差
In order to explore the relationship between clinical and immunopathological changes in pediatric hepatitis C (hepatitis C), eight cases of pediatric hepatitis C were studied on the basis of clinical, pathological and ultrastructural pathology, and the anti-hepatitis C virus C33c2B6 strain alone Clone antibodies, the liver corresponding to the detection of hepatitis C antigen (HCAg). The results showed that the liver HCAg detection rate was high (8/8 cases), but the number of positive cells was significantly lower than adults. Positive products and more localized in the cytoplasm. In the same period, serum anti-HCV and HCVRNA were detected, the positive rates were 50% (4/8 cases). Prompted liver immune pathology and ultrastructural pathology no correlation. Hepatic HCAg-positive cells in the smaller number of more like abnormal liver function and pathological changes, the prognosis is poor