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苯是一种广泛使用的工业原料,同时是一种确定的遗传毒性致癌物,主要由其活性代谢产物——氢醌发挥毒性作用。氢醌本身普遍应用于黑白显影剂、橡胶防老剂、稳定剂和抗氧剂。氢醌可引起机体多系统毒性损伤,长期试验表明氢醌还是一种致癌剂。近年来有文献报道氢醌暴露可导致DNA甲基化水平发生改变,本文综述了氢醌可能通过调节DNA甲基化转移酶的活力、氧化应激损伤干扰、DNA损伤修复蛋白调控以及其他表观遗传学修饰的参与等影响DNA甲基化状态,旨在为预防氢醌乃至苯中毒提供参考依据。
Benzene is a widely used industrial raw material, but also a definite genotoxic carcinogen, mainly due to the toxic effects of hydroquinone, its active metabolite. Hydroquinone itself is widely used in black and white developers, rubber antioxidants, stabilizers and antioxidants. Hydroquinone can cause multiple systemic toxicity damage, long-term tests show that hydroquinone is a carcinogen. In recent years, it has been reported in the literature that hydroquinone exposure can change the level of DNA methylation. This review summarizes that hydroquinone may regulate the activity of DNA methylation transferase, oxidative stress damage, DNA damage repair protein regulation and other apparent Genetic modification involved in DNA methylation status, designed to prevent hydroquinone and benzene poisoning provide a reference.