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目的:探讨一氧化氮(NO)在癫癎 发病中的作用.方法:ip 40mg·kg-1·d-1戊四氮 30min前注射 25mg·kg-1的 NG-硝基-左旋-精氨酸(L-NNA),连续 22d,观察两组的行为改变及点燃串,同时对 3组动物海马,大脑皮质一氧化氮合酶(NOS)阳性神经元的变化输入图像扫描仪,对其胞体平均灰度值进行比较。结果:L-NNA可明显抑制戊四氮点燃模型;戊四氮点燃大鼠模型海马,大脑皮质神经元的NOS活性显著增高.结论:NO参与了戊四氮点燃模型的形成。
Objective: To investigate the role of nitric oxide (NO) in the pathogenesis of epilepsy. Methods: N-nitro-L-arginine (L-NNA) was injected at a dose of 40 mg · kg-1 · d-1 penta-tetrazolium for 30 min before injection of 25 mg · kg-1 for 22 consecutive days. The strings were lit at the same time. Changes of hippocampus and cortical nitric oxide synthase (NOS) positive neurons in three groups of animals were input into an image scanner to compare the average gray value of the cell bodies. Results: L-NNA significantly inhibited the pentylenetetrazole ignition model; NOS activity of hippocampus and cerebral cortex neurons in pentylenetetrazole-lighted rat model was significantly increased. Conclusion: NO participates in the formation of pentylenetetrazole ignition model.