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重组红细胞生成素(rHuEPO)已经广泛应用于临床有效地治疗肾性贫血,人们正期待着 rHuEPO 在肾移植方面也同样带来巨大的影响。本文重点介绍 rHuEPO 与肾移植方面有关的四个问题:(1)rHuEPO 对高度敏感肾移植受者的影响;(2)rHuEPO 对 CsA 药物动力学的影响;(3)肾移植后血清 EPO 水平和红细胞的产生;(4)rHuEPO 在肾移植患者中的临床应用。
Recombinant erythropoietin (rHuEPO) has been widely used clinically and effectively for the treatment of renal anemia, and the expectation is that rHuEPO will also have a huge impact on kidney transplantation. This article highlights four issues related to renal transplantation with rHuEPO: (1) the effect of rHuEPO on highly sensitive kidney transplant recipients; (2) the effect of rHuEPO on the pharmacokinetics of CsA; (3) the level of serum EPO and Erythrocyte production; (4) rHuEPO in renal transplant patients in clinical application.