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目的 :为了研究血管内皮因子在糖尿病 (DM )病人及血管并发症中的变化。方法 :用高效液相色谱法测定一氧化氮(NO)、放射免疫分析法测定内皮素 (ET)在 74例DM和 30例正常对照组水平 ,同时测定甲襞微循环。结果 :血浆NO水平低于对照组 (P <0 .0 1) ,血浆ET水平明显高于对照组(P <0 .0 1) ,随着并发症的增多及病情的加重血浆NO随之减少 ,ET随之增多 ,微循环血流速度DM组明显低于对照组 (P <0 .0 1) ,血浆NO与微循环血流速度呈直线正相关 ,NO与ET、ET与微循环血流速度均呈直线负相关。结论 :ET及NO在DM及并发症中起重要作用 ,其水平高低在一定程度上反映了DM及血管损伤的程度。
Objective: To study the changes of vascular endothelial factor in patients with diabetes mellitus (DM) and vascular complications. Methods: Nitric oxide (NO) was determined by high performance liquid chromatography (HPLC). The levels of endothelin (ET) in 74 cases of DM and 30 normal controls were determined by radioimmunoassay. The microcirculation of nail polish was also measured. Results: The level of NO in plasma was lower than that in control group (P <0.01), and the level of ET in plasma was significantly higher than that in control group (P <0.01). With the increase of complication and aggravation of disease, plasma NO decreased , ET increased, the microcirculation blood flow velocity in DM group was significantly lower than that in control group (P <0.01), plasma NO was positively correlated with microcirculation, NO, ET, ET and microcirculation Speed are negative linear correlation. Conclusion: ET and NO play an important role in DM and complications. The level of ET and NO, to a certain extent, reflects the extent of DM and vascular injury.