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目的 观察水飞蓟素磷脂复合物灌胃对硫代乙酰胺(TAA)所致大鼠急性肝损伤的保护作用。方法实验分7组,即正常对照组、模型对照组、阴性对照组(磷酯组)、阳性对照组(益肝宁组,即水飞蓟素组)、水飞蓟素磷脂复合物小、中、大剂量组。给药28天后,用硫代乙酰胺(TAA,20mg/kg)造模型。测定各组动物血清中AST、ALT、TP、ALB、LN、HA、PⅢP、CⅣ等指标的变化;并称肝重,计算肝脏指数。结果 与益肝宁(142mg/kg水飞蓟素)相比较,水飞蓟素磷脂复合物灌胃(150、300、600mg/kg)可显著降低硫代乙酰胺肝中毒模型肝损伤的严重程度。结论 水飞蓟素磷脂复合物体内保肝疗效比益肝宁为佳。该作用可能与水飞蓟素磷脂复合物比水飞蓟素的生物利用度高有关。
Objective To observe the protective effect of silymarin phospholipid complex on acute liver injury induced by thioacetamide (TAA) in rats. Methods The experiment was divided into 7 groups: normal control group, model control group, negative control group (phosphorus ester group), positive control group (Yiganing group, ie silymarin group), and silymarin phospholipid complex small, medium, and high dose groups. After 28 days of dosing, models were made using thioacetamide (TAA, 20 mg/kg). The serum AST, ALT, TP, ALB, LN, HA, PIIIP, CIV and other indicators were measured in each animal group. The liver weight was calculated and the liver index was calculated. Results Compared with Yiganning (142 mg/kg silymarin), silymarin phospholipid complexes administered intragastrically (150, 300, and 600 mg/kg) significantly reduced the severity of liver injury in the thioacetamide-induced hepatotoxicity model. Conclusion Silymarin phospholipid complexes have more effective hepatoprotective effects than Yiganning. This effect may be related to the higher bioavailability of silymarin phospholipid complexes than silymarin.