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目的探讨坦索罗辛治疗输尿管下段结石效果。方法对86例单发输尿管下段结石患者在应用体外冲击波疗法治疗后随机分为坦索罗辛治疗组44例及保守治疗对照组42例。对照组每天饮水2 L以上,多运动,口服硝苯地平片10 mg/次,3次/d,必要时采用非甾体类抗炎药物缓解症状,疼痛难忍时用哌替啶50 mg肌内注射;治疗组除采用保守治疗外,加用坦索罗辛胶囊0.4 mg,1次/d;两组疗程均为2周。结果治疗组排石率为84.09%,对照组排石率为40.48%,两组比较差异有统计学意义(P<0.05);治疗组哌替啶使用率4.55%,对照组哌替啶使用率21.43%,两组比较差异有统计学意义(P<0.05)。结论坦索罗辛可以显著提高体外冲击波疗法后的结石排出率,减少发生肾绞痛概率,是输尿管下段结石体外冲击波疗法后辅助排石的有效治疗方法之一。
Objective To investigate the effect of tamsulosin in the treatment of lower ureteral calculi. Methods Totally 86 patients with lower ureteral calculi undergoing shock wave therapy were randomly divided into tamsulosin treatment group (n = 44) and conservative treatment control group (n = 42). The control group drinking more than 2 L per day more exercise, oral nifedipine tablets 10 mg / time, 3 times / d, if necessary, the use of non-steroidal anti-inflammatory drugs to relieve symptoms, pain when the use of pethidine 50 mg muscle In addition to conservative treatment, the treatment group was treated with tamsulosin 0.4 mg once daily for 2 weeks. Results The rate of discharged stone was 84.09% in the treatment group and 40.48% in the control group, with a significant difference between the two groups (P <0.05). The rate of use of pethidine in the treatment group was 4.55% 21.43%, the difference between the two groups was statistically significant (P <0.05). Conclusion Tamsulosin can significantly increase the rate of stone excretion after shock wave therapy in vitro and reduce the incidence of renal colic. It is one of the effective treatments for ancillary stone removal after extracorporeal shock wave therapy of ureteral calculi.