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伊伐布雷定是一种特殊的起搏电流(If)抑制剂,可用于降低心率,并具有潜在的抗心律失常作用。伊伐布雷定能降低由If引起的细胞自律性以及抑制房室结的传导速度,具有潜在的预防与治疗心房颤动和控制心房颤动心室率的作用。伊伐布雷定抑制HCN通道和If,对室性心律失常有一定的治疗作用。伊伐布雷定可抑制窦房结内的If,降低窦房结节律,从而稳定心率。伊伐布雷定目前的治疗价值尚缺乏大规模临床研究的证据支持,还需进一步深入研究。
Ivabradine is a special pessary current (If) inhibitor that reduces heart rate and has potential anti-arrhythmic effects. Ivabradine can reduce the cellular autonomic activity induced by If and inhibit the conduction velocity of atrioventricular nodules, with the potential to prevent and treat atrial fibrillation and control the ventricular rate of atrial fibrillation. Ivabradine inhibits HCN channels and If, to a certain therapeutic effect on ventricular arrhythmias. Ivabradine inhibits If in the sinus node, reducing the sinus node rhythm, thereby stabilizing the heart rate. The current therapeutic value of ivabradine is still lacking in the evidence support of large-scale clinical studies and needs further study.