Two novel analogues of triptolide were synthesized using triptolide as the starting materialthrough reductive opening of epoxy ring, hydration and olefin epoxidation, and related ketones havealso been afforded by oxidation of them with IBX or Jone’s reagent. Two novel analogues of triptolide were synthesized using triptolide as the starting materialthrough reductive opening of epoxy ring, hydration and olefin epoxidation, and related ketones havealso been afforded by oxidation of them with IBX or Jone’s reagent.