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目的:探讨非选择性肾上腺素能受体阻滞剂酚苄明(Dibenzyline)对良性前列腺增生症(BPH)伴急性尿潴留患者的治疗作用。方法:将155例BPH伴急性尿潴留患者随机分为治疗组和对照组。患者均行保留导尿,口服抗生素治疗,治疗组加用酚苄明10mg,2次/d,连续服用3天。72h后拔除导尿管。结果:拔除导尿管后46%(72/155)的患者能自行排尿。治疗组有效率为59%(51/86),对照组为30%(21/69),两组比较差异有显著性(P<0.05)。结论:对BPH伴急性尿潴留患者应用酚苄明治疗,可提高早期拔除导尿管后患者自行排尿的成功率,且副作用相对较小,价格便宜,适合临床推广应用。
Objective: To investigate the therapeutic effect of Dibenzyline, a non-selective adrenergic receptor blocker, on patients with benign prostatic hyperplasia (BPH) accompanied by acute urinary retention. Methods: A total of 155 BPH patients with acute urinary retention were randomly divided into treatment group and control group. All patients underwent catheterization and oral antibiotics. The treatment group was treated with phenoxybenzamine 10 mg twice daily for 3 days. After 72h remove the catheter. Results: 46% (72/155) of the patients with the catheter removed had their own urination. The effective rate was 59% (51/86) in the treatment group and 30% (21/69) in the control group, with significant difference between the two groups (P <0.05). Conclusion: The use of phenoxybenzamine treatment in BPH patients with acute urinary retention can improve the success rate of urinating in patients with early catheter removal, and the side effects are relatively small, the price is cheap and suitable for clinical popularization and application.