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65%～80%的卒中起因于脑动脉的急性血栓栓塞,脑血管造影(CAG)证实75%的病人发病6h 内即有大脑半球的梗死。脑对缺血的耐受性在数小时甚至1～3h 后即告丧失,早期脑血流的重建能限制梗死范围的扩大。因此,对缺血性卒中尽早采取积极的溶栓治疗是必要的。大约30年前,溶栓或纤溶疗法已应用于临床卒中的治疗。但在 CT 时代前,由于不能肯定地排除出血性卒中而未能得以广泛使用。
Sixty-five to eighty percent of strokes result from acute thromboembolism in the cerebral arteries. Cerebral angiography (CAG) confirms that hemispheres are infarcted within 6 hours of onset in 75% of patients. Brain tolerance to ischemia is lost in hours or even 1-3 h, and reconstruction of early cerebral blood flow can limit the extent of infarction. Therefore, aggressive thrombolytic therapy for ischemic stroke is necessary as soon as possible. About 30 years ago, thrombolytic or fibrinolytic therapy has been used in the treatment of clinical stroke. However, before the CT era, it was not widely used due to the uncertainty of hemorrhagic stroke.