间充质干细胞(MSCs)是组织再生的一个可靠来源,但其定向分化的分子机制仍不清楚,这限制了MSC的应用潜能。组蛋白脱甲基酶,又称赖氨酸-特异性脱甲基酶2A(KDM2A),是含有Jmj C结构的组蛋白脱甲基酶家族的成员,该家族进化保守且表达广泛。有研究表明KDM2A能调节MSCs的增殖和成骨/成牙本质向分化。KDM2A是否参与MSCs的其它多向分化还未可知。我们的研究表明,通过短发夹RNA沉默KDM2A可以增强人根尖乳头干细胞 Mesenchymal stem cells (MSCs) are a reliable source of tissue regeneration, but the molecular mechanism of their directional differentiation remains unclear, limiting MSC potential. Histone demethylase, also known as lysine-specific demethylase 2A (KDM2A), is a member of the histone demethylase family containing the JmjC structure, which is evolutionarily conserved and widely expressed. Studies have shown that KDM2A can regulate MSCs proliferation and osteogenic / odontoblast differentiation. Whether or not KDM2A participates in other multidirectional differentiation of MSCs is unknown. Our study shows that silencing of KDM2A by short hairpin RNA enhances human apical papillary stem cells