细胞间粘附分子-1(intereellular adhesion molecule-1,ICAM-1)是免疫球蛋白超家族成员之一,它不仅在多种肝病的发病机制中起重要作用,而且还与肝组织炎症活动程度、肝细胞损伤程度密切相关。而应用干扰素抗病毒治疗能有效的缓解肝组织的炎症活动。因此,ICAM-1水平和干扰素抗乙型肝炎病毒疗效的关系成为近期临床研究的热点。本文就近年来有关ICAM-1与干扰素抗乙肝病毒应答的关系综述如下。 Intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin superfamily, plays an important role not only in the pathogenesis of a variety of liver diseases but also in the degree of inflammatory activity , The degree of liver cell damage is closely related. The application of interferon antiviral therapy can effectively alleviate the inflammatory activity of liver tissue. Therefore, the relationship between the level of ICAM-1 and the efficacy of interferon against hepatitis B virus has become a hot topic in recent clinical research. This article in recent years on the ICAM-1 and interferon anti-hepatitis B virus response summarized as follows.