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[目的]探讨c-erbB-2在子宫内膜癌中表达及临床意义。[方法]采用免疫组化法检测子宫内膜癌、子宫内膜不典型增生和正常子宫内膜组织中c-erbB-2基因的表达,并分析其与临床病理的相关性。[结果]c-erbB-2基因的阳性表达率在子宫内膜癌组(34.62%)明显高于正常子宫内膜(11.11%)和子宫内膜不典型增生组织(13.79%)(P<0.05),并与子宫内膜癌的病理分级、临床分期、肌层浸润深度和淋巴转移明显相关(P<0.05),但与增生的程度无关(P>0.05)。[结论]c-erbB-2基因表达与子宫内膜癌的浸润、转移密切相关,可作为判断子宫内膜癌生物学行为及预后的重要参考指标。
[Objective] To investigate the expression of c-erbB-2 in endometrial carcinoma and its clinical significance. [Method] The expression of c-erbB-2 gene in endometrial carcinoma, endometrial dysplasia and normal endometrium was detected by immunohistochemistry, and its correlation with clinical pathology was analyzed. [Results] The positive rate of c-erbB-2 gene in endometrial carcinoma group (34.62%) was significantly higher than that in normal endometrium (11.11%) and endometrial dysplasia tissues (13.79%) (P <0.05) ), And was significantly correlated with pathological grade, clinical stage, depth of myometrial invasion and lymphatic metastasis (P <0.05), but not with the degree of hyperplasia (P> 0.05). [Conclusion] The expression of c-erbB-2 gene is closely related to the infiltration and metastasis of endometrial carcinoma, which may be used as an important reference index for judging the biological behavior and prognosis of endometrial carcinoma.