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最近环境致突变物和致癌物国际防护委员会(In-ternational Commission for Protection againstEnviromental Mutagens and Carcinogens,ICPEMC)收到许多要求对评定化学物质致突变性测试系统的选择加以指导,尤其是关于目前采用的那些实验的局限性方面的资料。ICPEMC 第一委员会(化学致突变物的鉴定和其特征确定的短期筛选方法的发展、评价和应用)已开始制定一些指标,对方法的适用程度进行评定。ICPEMC 主张目前应尽可能灵活地选择测试方法。被采用的筛选方法应能阐明导致基因突变、染色体损害。不分离现象(染色体)以及 DNA 初级损伤的化合物(或其代谢衍生物)。
Recently, the In-ternational Commission for Protection against Environments and Clinics (ICPEMC) received a great deal of guidance on the choice of test systems for assessing the mutagenicity of chemical substances, especially those currently in use Experimental limitations of the information. First Committee of ICPEMC (Development, Evaluation and Application of Short-Term Screening Methods for Identification of Mutants and Determination of Their Characteristics) Several indicators have been developed to assess the suitability of the method. The ICPEMC argues that the test method should now be as flexible as possible. The screening method used should be able to elucidate the cause of genetic mutations, chromosomal damage. Compounds (or their metabolic derivatives) that do not separate phenomena (chromosomes) and DNA primary damage.