Colon lipoma is remarkably rare in clinical practice. We reported a case of ascending colon lipoma in an 83-yearold woman. She was asymptomatic with a lipoma of 35 mmx30 mmx24 mm in size which was found by routine colonoscopy. Right hemicolectomy was performed uneventfully. The diagnosis was made by histological examination. Reviewing the literature and combining with our experience, we discussed the clinical features, diagnosis and treatment of this uncommon disease.