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目的 :探索放疗与化疗同步联合治疗食管癌的近期疗效。方法 :对50例食管癌患者进行随机对照试验 ,25例采用DDP加5 Fu联合放疗同步治疗(实验组) ,25例单纯放疗(对照组)。两组均采用常规分割放疗 ,每次2.0Gy,总剂量60～70Gy。实验组放疗第1、22天同时开始化疗 ,DDP总量达240mg,5 Fu总量3.0g。结果 :实验组肿瘤完全消退所需放射剂量低于对照组(P<0.01) ;放疗结束后病变完全消失率高于对照组 ,分别为76 %和20%(P<0.05)。1年生存率分别为72 %和32%(P<0.05)。结论 :放化疗同步治疗食管癌有明显协同作用 ,虽毒副反应加重 ,但尚可完成治疗
Objective: To explore the short-term curative effect of simultaneous radiotherapy and chemotherapy on esophageal cancer. Methods: Fifty patients with esophageal cancer were randomly divided into control group, 25 cases treated with DDP plus 5 Fu combined with radiotherapy (experimental group) and 25 cases with radiotherapy alone (control group). Both groups were using conventional radiotherapy, each 2.0Gy, the total dose of 60 ~ 70Gy. In the experimental group, chemotherapy was started on the 1st and 2nd day after radiotherapy. The total amount of DDP was 240mg and the amount of 5 Fu was 3.0g. Results: The radiation dose required for complete regression of the experimental group was lower than that of the control group (P <0.01). The rate of complete disappearance of the lesions in the experimental group was 76% and 20%, respectively (P <0.05). The 1-year survival rates were 72% and 32%, respectively (P <0.05). Conclusions: Chemotherapy and chemotherapy combined treatment of esophageal cancer have obvious synergistic effect, although the side effects of aggravation, but can still be completed treatment